骨缺损不仅由机械损伤引起，也可由肿瘤、感染或肌肉骨骼疾病引起。骨修复材料作为一种可促进骨再生的缺陷填充物，已成为当前骨再生医学的研究热点。相关研究重点涉及骨移植术后使用磁共振成像技术显影，需要造影剂增强信号强度来获得高质量图像。磁性骨修复材料能够在无需使用造影剂的情况下进行直接磁共振成像，骨科诊疗一体化领域具有重要意义。

       本研究合成了具有磁性的掺钆β-TCP生物材料，也证实了该材料的生物相容性以及具有相当强的磁性，使其在骨植入术后生物成像方面的应用成为可能。

        本文的主要研究内容如下：

1. 采用三种方法合成掺钆β磷酸三钙：湿沉淀法、低温法和溶剂热法，并分析了不同反应参数对合成的影响。通过比较选择出纯度、原子比和形貌最佳的样品，从而寻找到最佳合成方法，并确认该方法结果的可重复性以便进一步研究。

2. 通过生物相容性试验检测材料对成骨细胞的影响，证实其作为骨再生材料的适用性。

3. 在磁共振成像检测中证实了材料的磁性，该材料显示出了比纯β-TCP样品更高的磁化率。

       综上所述，本研究初步证实了合成的掺钆β-TCP材料在骨植入相关应用中具有潜力，可以兼具促骨再生以及植入部位术后诊断。

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