羟基磷灰石（HA）有着良好的的生物相容性、生物学活性，同时也具有一定的骨诱导性，羟基磷灰石作为人体骨组织最主要的的无机成分之一受到了人们的广泛关注并且应用在骨组织修复和骨缺损的填充过程中。虽然纳米羟基磷灰石粉体本身具有良好的生物相容性，但也存在一定的纳米细胞毒性。为避免上述问题，本论文通过微波水热法高效大量制备了氨基酸改性的纳米羟基磷灰石粉体，所制得的粉体具有晶粒尺寸小，长径比低，形貌十分均匀的特点，并且细胞毒性较小，然后将阿霉素（DOX）负载到羟基磷灰石粉体上，发现对骨肉瘤细胞具有一定的抑制作用。

       （1）通过微波水热法，研究了反应的pH以及不同氨基酸投料比对生成的羟基磷灰石粉体的影响。结果表明，保持反应温度为160℃，保温反应时间为40 min，所制得的纳米羟基磷灰石粉体为棒状，当氨基酸与钙离子的摩尔比为1.5时纳米粒子长度为64.7±13.6nm，直径为29.1±3.9nm。

（2）不同氨基酸投料比对羟基磷灰石的晶粒尺寸以及分散性有影响，因此通过不同浓度氨基酸改性的羟基磷灰石粉体的比表面积存在差异，通过制得的纳米羟基磷灰石粉体作为药物载体负载阿霉素（DOX），研究了不同氨基酸改性的羟基磷灰石粉体的载药能力以及对骨肉瘤细胞的抑制作用。苏氨酸改性的羟基磷灰石粉体负载阿霉素后有较明显的抑制骨肉瘤的作用。

（3）利用微波水热法制备不同氨基酸改性的纳米羟基磷灰石粉体，通过形貌分析和体外细胞实验，我们发现苏氨酸改性的羟基磷灰石粉体对小鼠成骨细胞的毒性较小，同时对骨肉瘤细胞有较明显的抑制作用。

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